MY JNS: Alerts
Welcome Guest User!
Publish Before Print
Back to TOC
You have requested the following article: Induction of glioblastoma multiforme in nonhuman primates after therapeutic doses of fractionated wholebrain radiation therapy Russell R. Lonser, Stuart Walbridge, Alexander O. Vortmeyer, Svetlana D. Pack, Tung T. Nguyen, Nitin Gogate, Jeffery J. Olson, Aytac Akbasak, R. Hunt Bobo, Thomas Goffman, Zhengping Zhuang, Edward H. Oldfield, Journal of Neurosurgery, December 2002 / Vol. 97 / No. 6 : Pages 1378-1389
Abstract Object. To determine the acute and long-term effects of a therapeutic dose of brain radiation in a primate model, the authors studied the clinical, laboratory, neuroimaging, molecular, and histological outcomes in rhesus monkeys that had received fractionated whole-brain radiation therapy (WBRT).
By Keywords: brain, glioblastoma multiforme, radiationinduced tumor, Macaca mulatta
Methods. Twelve 3-year-old male primates (Macaca mulatta) underwent fractionated WBRT (350 cGy for 5 days/week for 2 weeks, total dose 3500 cGy). Animals were followed clinically and with laboratory studies and serial magnetic resonance (MR) imaging. They were killed when they developed medical problems or neurological symptoms, lesions appeared on MR imaging, or at study completion. Gross, histological, and molecular analyses were then performed. Nine (82%) of 11 animals that underwent long-term follow up (> 2.5 years) developed neurological symptoms and/or enhancing lesions on MR imaging, which were defined as glioblastoma multiforme (GBM), 2.9 to 8.3 years after radiation therapy. The GBMs were categorized as either unifocal (three) or multifocal (six), and were located in the supratentorial (six), infratentorial (two), or both (one) cranial regions. Histological examination revealed distant, noncontiguous tumor invasion within the white matter of all nine animals harboring GBMs. Novel interspecies comparative genomic hybridization (three animals) uniformly showed deletions in the GBMs that corresponded to chromosome 9 in humans. Conclusions. The high rate of GBM formation (82%) following a therapeutic dose of WBRT in nonhuman primates indicates that radioinduction of these neoplasms as a late complication of this therapy may occur more frequently than is currently recognized in human patients. The development of these tumors while monitoring the monkeys' conditions with clinical and serial MR imaging studies, and access to the tumor and the entire brain for histological and molecular analyses offers an opportunity to gather unique insights into the nature and development of GBMs.
Pay Per Article
If you have an individual subscription to this content, or if you have purchased this content through Pay Per Article within the past 24 hours, you can gain access by logging in with your username and password here: JNS Users / AANS SSO login Institution Login
Journal of Neurosurgery - 97(6):Pages 13781389; Induction of glioblastoma multiforme in nonhuman primates after therapeutic doses of fractionated whole-brain radiation therapy, Electronic, Individual (access 24 hours for US $35.00)
OpenAthens login Activate your access If you're a print subscriber and haven't activated your access, or need help, please email us at
Subscription or Book Purchase Online You can also purchase online an Individual or Institutional Subscription to this journal or buy one or more printed volumes. An Individual Subscription to the journal grants: online access to all articles in the current volume a print copy of the current volume Note: Fulfillment of a Subscription (including online Activation) may take several business days. To gain access to an article immediately, use the Pay Per Article feature.
Reprints and Permissions
Mobile Contact Us
© Copyright 1944-2018 American Association of Neurological Surgeons